This research investigates how cells repair dangerous DNA double-strand breaks through the non-homologous end joining pathway. By identifying key proteins involved in this error-prone repair process, the work reveals new opportunities to sensitise cancer cells to radiation and chemotherapy, potentially improving treatment outcomes for aggressive cancers.

Respiratory Syncytial Virus (RSV) hospitalises thousands of children each year, yet effective treatments remain unavailable. This research investigates a critical protein–protein interaction that enables RSV infection. By identifying and disrupting key molecular binding sites using AI, the work aims to support the development of targeted antiviral therapies for severe RSV.

This research develops a protein-based detection technology capable of identifying subtle molecular changes months before disease symptoms appear. By adapting nanopore sequencing with a protein “detangler,” it enables early warning for conditions like leukemia, shifting medicine from reactive treatment to proactive disease prevention.

Intestinal cells protect us from harmful bacteria by forming a physical barrier and raising immune danger signals when needed. This research reveals a nuclear “knight” molecule that suppresses unnecessary immune activation during metabolic stress, helping maintain intestinal health and preventing excessive inflammation.

Malaria infects hundreds of millions each year by using the parasite Plasmodium to invade the liver through the CSP protein. This research designs tightly binding antibodies to block infection at its earliest stage, improving vaccine effectiveness and offering a path toward preventing malaria before symptoms begin.

This research develops a rapid, light-based method to study viral fusion, the first step of infection. By applying split NanoLuc technology to HIV, it reveals strain-specific fusion behaviors and unexpected regulatory steps, providing tools that can accelerate responses to future pandemics such as COVID-19.

This research investigates how different low-calorie sweeteners interact with the body’s sweet-taste receptor and influence biochemical signaling. By measuring the molecular “messenger” responses triggered by various sweeteners, the project aims to identify which ones have healthier metabolic effects, supporting better choices for weight management, diabetes, and general well-being.

The talk highlights how biology involves unseen interactions and how distinguishing living from dead microorganisms is essential. Using the chemical PMA (propidium monoazide), researchers can identify active pathogens and reduce misinterpretation in diagnostic tests, especially for viruses that cannot be grown in labs. This technique helps improve diagnostics, guide treatments, and advance microbiological research.

This research provides the first-ever map of the honeybee gut protein interactome to understand how the parasite Nosema disrupts bee health. By isolating gut protein interactions and identifying them via mass spectrometry and computational analysis, the project uncovers how infection alters essential networks, paving the way for targeted, safer treatments for honeybee disease.

This research aims to solve the major weakness of mRNA vaccines—the need for constant cold storage—by packaging them inside ultra-stable protein “boxes” called encapsulins. These naturally robust containers protect mRNA in extreme environments. A working prototype now exists, offering the potential for globally distributable, freezer-free vaccines that remain effective anywhere.