This research investigates Large Granular Lymphocyte Leukemia, where protective T cells become cancerous. The project explores how DNA methylation silences normal T-cell function and tests drugs that reverse this process. By removing harmful chemical modifications, the goal is to restore immune cells to their healthy, protective “superhero” role.

This research investigates HMGN proteins, which organize the genome and help cells access the correct genes. By mapping their activity and removing them with CRISPR, the study shows that HMGNs act as DNA “librarians.” Their dysfunction leads to gene misregulation linked to many diseases.

This research tests whether positive, therapy-induced epigenetic changes can be inherited. Using mice with genetic eye disease, the team applies a successful treatment, checks for vision improvement, examines resulting DNA chemical marks, and studies whether offspring inherit these beneficial modifications. Findings could reshape our understanding of therapy and generational health impact.