This research investigates how aging changes blood stem cells, causing them to produce excess sticky platelets that increase the risk of heart attack and stroke. By identifying the genetic mechanisms behind this age-related shortcut, the work aims to develop therapies that reduce cardiovascular disease while improving healing in patients with low platelet counts.

This research uses agent-based mathematical modelling to study keloid scar growth. By simulating interactions among collagen, immune cells, and key scar-associated cell types, the model predicts how keloids expand without requiring harmful patient experiments. The approach may guide future treatments for keloids and broader skin-healing conditions.

This research develops 3D-printed hydroxyapatite scaffolds that actively stimulate bone regeneration. Unlike traditional bone grafts, these synthetic scaffolds recruit stem cells and encourage new bone formation. Animal studies show promising healing results, raising the possibility of personalised, patient-specific implants that improve recovery from severe bone injuries and defects.

This research investigates macrophages, immune cells that regulate infection, tissue repair, and cancer responses. Through laboratory experiments and machine-learning models, it aims to predict macrophage function across different diseases and patients. The work could improve prognosis, guide treatments, evaluate drug safety, and forecast recovery following major illnesses and injuries.

Despite major advances in medicine, wound care has changed little in a century. This research explores how natural electrical signals in injured skin guide healing. By developing devices that mimic these signals, scientists aim to accelerate recovery and improve treatment for chronic wounds through bioelectric control of cellular behaviour.

This research develops injectable, enzyme-coated gel beads to treat bone fractures non-invasively. Using lab-on-a-chip technology, the beads trigger clot formation at injury sites, supporting natural healing while providing structural stability. This approach could reduce reliance on surgery, improve recovery outcomes, and address non-healing fractures affecting millions annually.

This thesis developed multifunctional 3D-printed scaffolds for repairing critical-size mandibular bone defects. Using bioactive ceramics, surface coatings, and prevascularization strategies, it promoted both osteogenesis and angiogenesis. Results show that combining geometry, materials, and biological signals enables synergistic tissue regeneration, offering less-invasive alternatives to autologous bone grafts.

This research improves the safety of stem cell–derived heart cell therapy for heart failure by engineering a drug-controlled genetic safety switch. The approach prevents dangerous post-transplant arrhythmias while allowing transplanted cells to mature and synchronize with the heart, advancing regenerative alternatives to full heart transplantation.

This research develops smart, biodegradable bone scaffolds that guide regeneration in severe fractures. By delivering healing molecules directly to damaged tissue, the scaffolds promote stronger bone growth, reduce inflammation, and eliminate the need for repeated surgeries, enabling faster and more natural recovery in children.

Myelin enables efficient communication between nerve cells and is essential for cognition, movement, and sensation. In neurodegenerative diseases, myelin is lost, impairing daily life. This research uses stem cells, gene profiling, and gene editing to uncover why myelin fails—and how regenerating it could transform treatment.