This research investigates how the structure of comb polymers influences their ability to stabilize materials in applications ranging from fragrances and food products to wastewater treatment and drug delivery. By systematically modifying polymer architecture, the study identifies design rules that enable more effective, affordable, and targeted performance across diverse industrial and medical uses.

This research uses a computational method called MELT to identify hidden allosteric pockets in shape-shifting proteins like BCR–ABL kinase. By targeting these pockets, drugs can stabilize inactive protein states, overcoming resistance caused by protein flexibility and enabling more effective, adaptable strategies for drug discovery.