This research investigates polyploid giant cancer cells, a highly treatment-resistant population responsible for cancer relapse. By studying their structural biology and dependence on lipid metabolism, the work identifies metabolic vulnerabilities that can be targeted alongside chemotherapy, offering a promising strategy to eliminate resistant cancer cells and improve long-term treatment outcomes.

Mitochondria are known as the cell’s powerhouses, but new research shows they also guide cell movement. Using advanced imaging, this work reveals how mitochondria control direction and speed of migrating cells. Understanding this process may explain wound healing and how cancer cells spread throughout the body.