This research investigates the genetic mechanisms underlying polycystic ovary syndrome (PCOS), a condition affecting one in ten women and the leading cause of female infertility. By studying thousands of genetic variants across multiple cell types, the project aims to identify the biological causes of PCOS and develop targeted treatments.

This research challenges the one-size-fits-all approach to obesity by comparing childhood- and adult-onset cases. Through physiological testing before and after weight loss, it examines differences in inflammation, metabolism, and fitness. Findings aim to support personalised treatments, improving patient outcomes and reducing the broader healthcare burden associated with obesity.

Obesity and type 2 diabetes weaken bones, increasing fracture risk. This research uses animal models of lean, obese, and diabetic conditions to examine how these diseases affect bone strength. By identifying the mechanisms behind bone fragility, the study aims to guide future dietary and therapeutic strategies to protect bone health in affected populations.