This research develops a method to deliver EGCG, a green tea compound known to break apart Alzheimer's-related protein tangles, into the brain. By chemically attaching EGCG to a carrier that can cross the brain's protective barrier, the project aims to create a potential therapeutic strategy for slowing memory loss and disease progression.

Prion diseases like CJD are extremely hard to detect early because harmful prions resemble normal brain proteins. This research introduces a new “flashbody” detection tool that binds only disease-causing prions, providing rapid, accurate, equipment-free diagnosis. Early lab results and patient-screening trials are promising, with potential applications to Alzheimer’s and other dementias.