This research uncovers how two proteins, GluA1 and PKC, regulate behavioural flexibility in the striatum. Deleting GluA1 causes animals to get “stuck,” mirroring symptoms in OCD, addiction, and autism. A new molecular tool restores flexibility by 80% in hours, offering a potential pathway for future neuropsychiatric treatments.

This research focuses on developing reliable blood-based biomarkers to evaluate new treatments for hereditary frontotemporal dementia. By identifying an imbalance between two key molecules, progranulin and prosaposin, the work aims to provide accurate measures of treatment effectiveness and bring hope to families carrying this devastating genetic condition

This research maps how drugs travel from the cerebrospinal fluid into the brain, offering an alternative to the blood–brain barrier for treating Alzheimer’s disease. Using mouse models, the study identifies specific drug-entry routes and differences in drug penetration, paving the way for targeted, efficient therapies guided by a “Google Brain Map” of delivery pathways.

Migraine affects over a billion people, yet its cellular mechanisms remain unclear. This research studies how CGRP-blocking drugs interact with two key receptors—CGRP and AMY1—to understand why treatments help some patients but not others. The findings may guide development of more effective, targeted migraine therapies and reduce debilitating attacks.

Brain surgeons struggle to distinguish tumor from healthy tissue in real time, risking life-altering surgical mistakes. This research uses polarimetric imaging and machine-learning algorithms to reveal tumor borders instantly by analysing subtle differences in tissue structure. Faster, clearer, real-time imaging could revolutionise brain surgery and dramatically improve patient outcomes.

This research compares three experimental models of anxiety — threat of shock, CO₂-induced panic, and speech-induced social anxiety — to reveal how each affects cognition. Findings show distinct patterns in attention, memory, and loss aversion, offering insights that could improve and better tailor treatments for anxiety disorders.

This research investigates how children use the left and right hemispheres for language and spatial reasoning. Using ultrasound while children play custom games, it shows that those with the typical left-language/right-spatial pattern tend to have stronger skills. The findings reveal how brain-activity patterns relate to developmental risks and complex tasks like reading.

The researcher rebuilds how cells sort materials to understand Alzheimer’s and Parkinson’s diseases. Using proteins and lipids like Lego pieces, they study how a key protein, retromer, malfunctions and disrupts cell transport. With cryogenic electron tomography, they aim to model this process and guide new treatments that restore healthy cellular function.