This research investigates how antiviral drug resistance develops by examining structural changes in viral proteins. Using protein crystallography, it identified why SARS-CoV-2 mutations prevent Paxlovid binding and discovered two compounds capable of inhibiting resistant viruses. The findings could guide development of more effective antivirals against future drug-resistant viral infections.

Marine-feeding vampire bats provide a novel way to track how viruses move between wildlife, livestock, and humans. By analysing their feeding history, researchers can trace cross-species disease transmission, including links between ocean-origin viruses and farm animals, offering early warning signs that could help prevent future pandemics.