This research investigates how T cells influence microglial behavior in Alzheimer’s disease. Using a mouse model, the study found that removing T cells did not alter amyloid-beta plaques but unexpectedly led to healthier microglial activity and reduced myelin damage. The findings suggest T cells may worsen neurodegeneration and reveal new therapeutic avenues.

This research targets the earliest stage of allergic and asthmatic immune reactions by blocking key cytokine “messages” sent from T cells to B cells. Using drug-discovery techniques, the project identifies compounds that prevent immune overreaction before symptoms begin, aiming to develop a new class of long-lasting preventative allergy and asthma treatments.