This research investigates therapy-resistant persister cells in lung cancer using single-cell analysis of patient tumors before, during, and after treatment. Findings show persister cells survive by entering a dormant state and activating the cilia–FGFR4 survival pathway. Targeting this pathway could eliminate persister cells and prevent relapse in patients.

My research develops a gentle cancer treatment using ultrasound to activate specialised LDH particles inside tumour cells. These particles release ROS “micro-explosions” that kill cancer without surgery or chemotherapy. Enhanced with MRI-visible metals, the method offers a safe, targeted therapy that destroys breast cancer cells using sound instead of pain.

This research investigates a novel two-drug therapy for ovarian cancer that kills cancer cells without harming healthy tissues and partially reactivates the suppressed immune system. The PhD work explores how this immune “reawakening” occurs, aiming to identify new strategies to enhance it and create more effective, resistance-proof treatments.