Genetic Disruption of CAPNS1 Impedes Triple-Negative Breast Cancer Metastasis - Danielle Harper

Year
2025
Organisation
Queen's University Canada
Tags
Breast Cancer Metastasis
Calpain Protein
Cell Migration
Focal Adhesion
Cancer Cell Movement
Metastatic Cancer
Gene Editing In Cancer
Mouse Models Cancer
molecular oncology
targeted therapy
Cancer Combination Therapy
Tumor Spread
Summary

This research investigates how calpain, a protein that regulates cell movement, contributes to breast cancer metastasis. By disrupting calpain in tumor cells, researchers show reduced spread to the lungs in mouse models. Targeting calpain may improve combination therapies and offer new treatment strategies for metastatic breast cancer patients.