This research investigates how calpain, a protein that regulates cell movement, contributes to breast cancer metastasis. By disrupting calpain in tumor cells, researchers show reduced spread to the lungs in mouse models. Targeting calpain may improve combination therapies and offer new treatment strategies for metastatic breast cancer patients.

This research investigates therapy-resistant persister cells in lung cancer using single-cell analysis of patient tumors before, during, and after treatment. Findings show persister cells survive by entering a dormant state and activating the cilia–FGFR4 survival pathway. Targeting this pathway could eliminate persister cells and prevent relapse in patients.