This research combines focused ultrasound and engineered genetic circuits to activate cancer immunotherapy directly within solid tumors. By locally triggering immune-stimulating cytokines such as IL-12, the approach aims to convert “cold” tumors into “hot” tumors while minimizing systemic toxicity, potentially expanding curative immunotherapy treatments to more cancer patients.

This neuroscience research investigates how the brain assigns value during decision-making. Using low-intensity focused ultrasound and human single-neuron recordings, the study examines the ventromedial prefrontal cortex and its role in transforming perception into choices. The findings may improve understanding of disorders such as obsessive-compulsive disorder and maladaptive decision-making.