This research develops gold nanoparticles coated with peptides to block DNA repair in colorectal cancer cells, helping overcome drug resistance. Laboratory studies show the treatment dramatically reduces cancer cell survival after radiation while minimising toxicity. The approach could provide a safer, more effective therapy for colorectal cancer and other drug-resistant cancers.

IBD patients have weakened gut microbes, leaving them with chronic inflammation and limited treatment options. This research engineers probiotic yeast with anchors, drug-carrying “backpacks,” and reprogrammed DNA to deliver targeted therapeutics safely and cheaply. Early results show these modified microbes could become effective, low-side-effect treatments for IBD and other gut diseases.