This research investigates how mechanical forces regulate cell movement using a novel DNA-based force probe. By measuring the force required to halt actin growth, it provides new insights into the mechanics of cell migration. The findings could ultimately help develop strategies to prevent cancer metastasis by controlling tumour cell movement.

This research investigates polyploid giant cancer cells, a highly treatment-resistant population responsible for cancer relapse. By studying their structural biology and dependence on lipid metabolism, the work identifies metabolic vulnerabilities that can be targeted alongside chemotherapy, offering a promising strategy to eliminate resistant cancer cells and improve long-term treatment outcomes.

This research investigates how glioblastoma brain cancer cells invade healthy brain tissue. Using patient-derived tumor organoids and traction force microscopy, the study measures how cancer cells generate and apply forces to move through the brain. Understanding these invasion mechanisms could help develop therapies that slow tumor spread and improve patient survival.