This research explores endophytes—fungi living symbiotically within plants—that produce bioactive compounds aiding plant defense and growth. These compounds have led to major medical breakthroughs like antibiotics and immunosuppressants. Studying endophytes in crops may uncover new drugs and agricultural benefits, highlighting nature’s vast, largely untapped biochemical potential.

This research develops synthetic communities of beneficial xylem-inhabiting bacteria to control olive vascular diseases caused by Verticillium dahliae and Xylella fastidiosa. Over 300 bacterial strains were screened for biocontrol traits, and compatible candidates were combined into effective communities. Preliminary plant trials show promising results for sustainable, microbiome-based disease management.