This research applies fluid mechanics, numerical simulations, and machine learning to model the brain’s waste-clearance system during sleep. By investigating how fluid moves through brain tissue and how aging or injury affect this process, the work aims to identify strategies for preventing or slowing neurodegenerative diseases such as Alzheimer's.

This research investigates the neurological causes of sleep dysfunction in people with myotonic dystrophy, a common multisystem muscular dystrophy. Using mouse models and brain activity monitoring, the study examines how diseased brains lose the ability to compensate for stress, providing new insights into sleep quality, cognition, and disease progression.