This research develops pH-responsive biomaterials to deliver chemotherapy directly to glioblastoma cells in the brain. By releasing drugs in the presence of cancer while remaining closed around healthy tissue, the approach aims to improve treatment effectiveness, reduce harmful side effects, and ultimately enhance patients’ quality of life and survival.

This research investigates how glioblastoma brain cancer cells invade healthy brain tissue. Using patient-derived tumor organoids and traction force microscopy, the study measures how cancer cells generate and apply forces to move through the brain. Understanding these invasion mechanisms could help develop therapies that slow tumor spread and improve patient survival.

This project develops an “Aptamer Express,” a DNA-based Trojan horse designed to bypass the brain’s protective barriers, target tumours, and deliver cancer-killing drugs directly to brain cancer cells. The approach aims to overcome treatment resistance, improve precision, and reduce side effects, offering new hope for patients and their families.