This research investigates how declining ovarian health influences brain aging and dementia risk. Using genetically engineered mouse models, it identifies inflammation and metabolic stress in the hippocampus associated with low egg quality, suggesting that treatments targeting menopause, hormonal imbalance, or insulin resistance could help protect cognitive health and prevent dementia.

This research develops a non-hormonal male contraceptive by blocking two sperm proteins, Catsper and SLO3, that enable hyperactivated “power swimming” required for fertilization. By designing molecules that inhibit these proteins, the project aims to create a safe, reversible contraceptive option that avoids hormonal side effects.

This research investigates how a gonorrhea protein is processed in E. coli using cellular signal sequences, which act like "ZIP codes" directing the protein to its proper location. By identifying effective signal sequences, the study informs potential molecular targets for earlier detection and better treatment, aiming to prevent gonorrhea-related infertility and improve women's reproductive health.