Balanced cell growth is essential: too much can cause cancer, too little can cause skeletal disorders. This PhD project investigates a mysterious protein linked to dwarfism. By tagging it with GFP, the researcher discovered it drives fat-droplet formation, revealing a previously unknown function that may explain its powerful effects on body growth.

A hidden evolutionary arms race unfolds between bacteria and the viruses that attack them. By understanding how bacteria cut and rearrange DNA through recombination, researchers can harness these mechanisms for precise gene editing. This work could enable powerful new treatments for genetic diseases, helping patients like the first personalised-therapy recipient, KJ.

The researcher rebuilds how cells sort materials to understand Alzheimer’s and Parkinson’s diseases. Using proteins and lipids like Lego pieces, they study how a key protein, retromer, malfunctions and disrupts cell transport. With cryogenic electron tomography, they aim to model this process and guide new treatments that restore healthy cellular function.