The Heart's Hidden Shield Against Cancer - Amid Shakeri

Year
2025
Organisation
University of Toronto
Tags
Cancer Metastasis Research
Organ-on-Chip Technology
Heart Cancer Resistance
tumor microenvironment studies
Microfluidic Disease Models
3D Printing Biomaterials
Stem Cell Heart Tissue
Cancer Cell Migration
Vascular Permeability Models
Biomedical Engineering Cancer
Anti-Metastatic Mechanisms
translational cancer research
Summary

This research investigates why cancer rarely metastasizes to the heart using a microfluidic organ-on-chip model. By comparing cancer cell migration across tissues, it finds reduced spread in the presence of heart tissue, potentially due to inhibitory proteins. The work aims to uncover mechanisms that could inspire new anti-metastatic therapies.