Can Immune Cells See the Disease? - Kartik Lakhotiya

Year
2026
Organisation
Case Western Reserve
Tags
aplastic anemia immunology
immunopeptidomics research
peptide antigen presentation immune system
hematopoietic stem cell autoimmunity
immune visibility score concept
antigen peptides immune targeting
autoimmune disease peptide analysis
immune system cell recognition
precision immunology diagnostics
peptide biomarkers autoimmune disease
immune cell targeting mechanisms
mass spectrometry immunopeptidomics
Summary

Aplastic anemia occurs when immune cells attack blood-forming stem cells. Current diagnostics rely on DNA and RNA signals, which may not reflect what immune cells truly detect. Using immunopeptidomics, this research analyzes peptide fragments displayed on cells to measure immune visibility and identify precise immune targets for improved diagnosis and treatment.