The Brain’s Roundabout: Understanding Stroke in Adults with Sickle Cell Disease - Lara Abdelmohsen

Year
2026
Organisation
Carnegie Mellon University
Tags
Circle Of Willis
Sickle Cell Disease
stroke risk prediction
Cerebral Blood Flow
MRI Modelling
Patient Specific Models
Computational Medicine
Hemodynamics
Non Invasive Diagnostics
Brain Circulation
Ultrasound Limitations
biomedical engineering
Summary

This research examines stroke risk in sickle cell disease by modelling blood flow in the Circle of Willis. While ultrasound predicts risk in children, it fails in adults. Using MRI-based, patient-specific simulations, the study identifies major differences in blood flow patterns, offering a non-invasive, more reliable method for adult stroke prediction.